ALZHEIMER'S DISEASE CENTER AWARDED FIVE-YEAR, $4.4 MILLION NIH GRANT RENEWAL

October 23, 1996

Media Contacts: Sarah Goodwin, 404/727-3366 - sgoodwi@emory.edu
Kathi Ovnic, 404/727-9371 - covnic@emory.edu
http://www.emory.edu/WHSC/

Investigators at the Alzheimer's Disease Center (ADC) based at the Emory University School of Medicine and the Atlanta Veterans Affairs Medical Center (VAMC) have been given the opportunity through a $4.4 million National Institutes of Health grant renewal, to further expand the rich base of research, treatment and education programs they have fostered over the past five years. The additional federal funds support the ADC through the year 2001.

"Since its inception in October of 1991, the Emory ADC has fulfilled its initial goal of supporting and stimulating Alzheimer's disease research at Emory," says ADC Principal Investigator and Director Suzanne S. Mirra, M.D., who is professor of pathology (neuropathology) at the Atlanta VAMC and Emory University School of Medicine. "The extraordinary growth of the basic and clinical neuroscience community at Emory has only increased the need for the core support provided by the center."

The impact of the ADC on the scientific community and the community-at-large has been substantial -- and varied. Activities range from connecting every second year Emory medical student with the family of an individual with Alzheimer's disease, to looking for Alzheimer's genes, to maintaining an active "brain bank" of tissue available for study, to presenting puppet shows on the condition to youngsters, to studying the effects of estrogen on Alzheimer's disease progression, to recruiting junior investigators to the field through pilot project grants.

A significant contribution of the ADC to the field of Alzheimer's disease research has been its emphasis on the investigation and treatment of the disease in African-Americans. Emory neurologists evaluate and treat patients at an urban Satellite Clinic, pathologists characterize brain tissue from older African-Americans with and without Alzheimer's disease, ADC staff provide multicultural symposia on Alzheimer's disease to the public, and have organized an annual high school career day emphasizing exposure of minority students to career opportunities in the Alzheimer's disease field.

"Representation of minority patients increased from six to 29 percent over the past four years as a result of recruitment of African-American subjects through our Satellite Clinic," Dr. Mirra says. "The high proportion of African-American subjects seen through the Clinical Core, paralleling that of our regional population, will enable us to obtain much needed information on dementia in this understudied group."

Two additional research themes have emerged from the ADC; one focuses on common threads among movement disorders such as Parkinson's disease and dementias such as Alzheimer's; the other evaluates the mitochondrial genetics of these disorders.

"In a setting of quality patient care, family support and education, the Clinical Core will provide (to investigators) information on well characterized groups of Alzheimer's disease patients, Parkinson's disease patients with and without dementia, and normal individuals free of cognitive and motor impairment," says ADC Associate Director Mahlon DeLong, M.D., chairman of Neurology at Emory and an international expert on movement disorders.

The Molecular Biology core will assess mtDNA (mitochondrial DNA) abnormalities associated with Alzheimer's disease and aging, and will screen for mutations known to be associated with early-onset familial and late-onset Alzheimer's disease.

Other ADC leaders include: Allan Levy, M.D., Ph.D., Clinical Core; Alexander Auchus, M.D., Satellite; Herbert Karp, M.D., Education and Information Transfer; Douglas Wallace, Ph.D., Molecular Biology Core; and Linda McGuire, ADC administrator.

For more general information on The Robert W. Woodruff Health Sciences Center, call Health Sciences News and Information at 404-727-5686, or send e-mail to hsnews@emory.edu.